Although all of the cells can be damaged during oxidative stress episodes, sperm are particularly sensitive to damage caused by free radicals.
Reactive oxygen species (ROS) are environmental contaminants and by-products of energy production in the body and other cellular activities. Although some cellular ROS apply important physiological functions when produced in excess, which can affect both the quality and quantity of sperm.
Normally, seminal fluid contains antioxidants that eliminate the harmful effects of ROS; but if excessive amounts thereof occurring ROS imbalance and cause damage to the wall of the sperm cells and sperm DNA occurs. This leads to the production of low quality sperm and the results of infertility.
In addition, as the sperm with damaged DNA can cause miscarriages, occur with conditions such as achondroplasia (dwarfism) progeny childhood cancer trigger.
Two aggravating factors associated with idiopathic male infertility are infection and inflammation. Even low genitourinary infections "hidden" cause inflammation and an associated increase in the number of leukocytes (white blood cells) in male reproductive tissues. Both contaminants leukocytes and abnormal sperm contribute to increased production of ROS and oxidative stress compromises spermatogenesis other standard.
Other causes of oxidative stress associated with male infertility are smoking, aging, pesticides, exogenous estrogens, heavy metals and diseases such as diabetes.
Treatment of infertility caused by oxidative stress
Needless to say, you must first delete treatable causes oxidative stress such as diabetes, infections, smoking, etc. Once this is done, no laboratory test for determining whether oxidative stress in seminal fluid.
However, it is important to note that the ROS can have positive and negative effects on spermatozoa. The ratio of the amounts of ROS produced neutralized by antioxidant compounds will decide whether a given sperm function will be helped or hindered.
As several antioxidant compounds work at different stages of oxidative process is unlikely that taking high doses of antioxidant "strong" will only much more impact. In fact, high doses of antioxidants can all actually worsen the situation that some ROS such as hydrogen peroxide are key signaling molecules without which normal immune function is compromised.
It is recommended, therefore, that high doses of one or two antioxidant vitamins such as vitamin C, E and beta-carotene are not taken without careful consideration. Instead of a diet rich in foods containing antioxidants such as spices, fruits and vegetables provide a wide variety of natural antioxidant compounds. In fact, spices have the highest antioxidant activity of all kinds of food (American Journal of Clinical Nutrition in July 2006) and should be added to any meal or supplement based on balanced spices.
references
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Am J Reprod Immunol. January 2008; 59 (1): 2-11. Agarwal A, K Makker, R. Sharma
2. An evidence-based approach for the medical treatment of male infertility: a brief review. Int Urol. 2009; 82 (2): 125-9. Epub 2009 March 19. Ghanem H, Shamloul R.
3. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab. October 2005; 6 (5): 495-501, Sheweita SA, Tilmisany AM, Al-Sawaf H ..
4. The physiological and pathological levels of reactive oxygen species in the semen of fertile men sorted Steril. October 2008. 18. Desai N, R Sharma, Makker K, Sabanegh E, Agarwal A.
5. Relative impact of oxidative stress on male reproductive function Curr Med Chem 2001 June; 8 (7): 851-62. SC Sikka.
6. The role of reactive oxygen species in male infertility. Urology. December 1996; 48 (6): 835-50. RK Sharma, A. Agarwal
7. Utility evidence of oxidative stress in the clinical male infertility]
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